Genetic Cause of Statin-Related Muscle Pain Found

British researchers identify variant that increases risk of myopathy at high doses
Posted July 23, 2008

By Ed Edelson
HealthDay Reporter

WEDNESDAY, July 23 (HealthDay News) — British researchers have discovered a genetic variant that causes some people who take cholesterol-lowering statins to have the muscle weakness called myopathy.

“We found a variant that affects the transport of statins into the liver,” said Dr. Rory Collins, a professor of medicine and epidemiology at the University of Oxford and a leader of the group reporting the discovery in the July 24 online issue of the New England Journal of Medicine. “That variant produces a high level of blood statins and accounts for the greatest proportion of myopathy in people who use statins.” More…